Kate and her brutish boyfriend Big Al sell handguns on the streets of New York. She's smart, stylish, and self-confident, but all that leaves her when Al, in a jealous and self-indulgent rage, beats her. Three friends encourage her recovery: Vic, a woman who would like to be Kate's lover; Reilly, who runs with Al but also is attracted to Kate and repulsed by Al's violence; and, Liz, the counselor assigned to Kate from a battered-women's program. Vic and Reilly talk about killing Al, Liz gives pep talks; Kate remains frightened. Will Al's menace and Kate's dependency hold sway?

In a world ravaged by a virus infection, turning its victims into the Undead, Alice (Jovovich), continues on her journey to find survivors and lead them to safety. Her deadly battle with the Umbrella Corporation reaches new heights, but Alice gets some unexpected help from an old friend. A new lead that promises a safe haven from the Undead takes them to Los Angeles, but when they arrive the city is overrun by thousands of Undead - and Alice and her comrades are about to step into a deadly trap.

Survivors of the Raccoon City catastrophe travel across the Nevada desert, hoping to make it to Alaska. Alice joins the caravan and their fight against the evil Umbrella Corp.

In the colorful future, a cab driver unwittingly becomes the central figure in the search for a legendary cosmic weapon to keep Evil and Mr Zorg at bay.